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Jubilant Therapeutics Inc. to Present Data on Isoform Selective PAD4 inhibitors in the Treatment of Cancer at the American Association of Cancer Research Annual (AACR) Meeting 2022

Jubilant Therapeutics Inc. (‘Jubilant’), a biopharmaceutical company advancing small molecule precision therapeutics to address unmet medical needs in oncology and autoimmune diseases, announced today that it will present data on inhibitors of peptidyl arginine deiminase type-4 (PAD4), a potential therapeutic target to treat cancer and autoimmune diseases.The meeting will be held at the American Association of Cancer Research Annual (AACR) in New Orleans between April 8 to 13, 2022, both in person and virtually.

Details of the presentation are as follows:

Title: Novel, isoform selective PAD4 inhibitors for the treatment of Cancer
Presentation Type: Poster
Presenters: Luca Rastelli, Chief Scientific Officer
Dhanalakshmi Sivanandhan, Vice President – Discovery Biology
Session: Novel Targets and Pathways
Time and Date: 12th April 2022, 9:00 AM - 12:30 PM
Link to Abstract: https://www.abstractsonline.com/pp8/#!/10517/presentation/15071

About PAD4
Peptidyl Arginine Deiminase type-4 (PAD4) is an enzyme that converts protein arginine or mono-methylarginine to citrulline. The PAD4-mediated hypercitrullination reaction in neutrophils causes the release of nuclear chromatin to form a chromatin network termed Neutrophil Extracellular Traps (NETs). NETs have been shown to be associated with several pathological processes including cancer metastasis, fibrosis, ischemic stroke, preeclampsia, thrombosis and other autoimmune diseases. Jubliant Therapeutics Inc. is targeting PAD4 inhibition as a novel strategy to treat cancer progression & metastasis and autoimmune diseases without inducing immunosuppression as seen with most other agents approved for autoimmune diseases.


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